Rat liver 2-oxoglutarate dehydrogenase activity regulation by thiamine and its metabolites and co-enzymes

N. Fedorko, O. Ustjansky, S. Petrov

Mechnikov National University of Odessa
2, Dvoryanska St., Odessa 65066, Ukraine
ustjansky_olga@ukr.net

Regulation effects are in-process investigational by coferments and метаболитами thiamine of 2-oxoglutarate dehydrogenase complex. At the level of the partly cleared enzyme the oppressive operating of thiaminepyrophosphate and thiochrome is shown on activity of 2-oxoglutarate dehydrogenase. It is been established that thiamine and its metabolites supress of 2-oxoglutarate dehydrogenase activity at the level of decarboxylases componenty. Lipois acid causes a stimulanting effect at the level of the transacetylase componenty, which is necessary for regulation of activity of polienzyme complex at the variou conditions of in tissues.


Keywords: 2-oxoglutarate dehydrogenase, co-enzymes, thiamine, multienzyme complex


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