Influence of various genes modifiers nAchRA–30D and Cam on manifestation of mutant dystrophin phenotype in Drosophila melanogaster

Yu. Shalovylo1*, Ya. Chernyk1, R. Bilyy2, N. Holub1

1Ivan Franko National University of Lviv
4, Hrushevskyi St., Lviv 79005, Ukraine
2Danylo Halytskiy National Medical University of Lviv
69, Pekars’ka St., Lviv 79010, Ukraine

Influence of genes-modifiers nAchRα-30D and Cam on mutant phenotype after the dystrophin gene in Drosophila melanogaster have been investigated. For the study of their action the individuals containing the probed gene-modifier and genetic construction for the diminished expression of dystrophin gene have been got. Partial restore of wing veins and muscle structure, increase of maximal and mean life-span, move activity index and R-cell elongation has been revealed. Changes of these attributes are the characteristic signs of mutants after the dystrophin gene.

Keywords: Drosophila, dystrophin, gene-modifier, , nAchRα-30D, Cam

Full text (PDF)