Screening for genes that cause neurodegenerative phenotype in Drosophila melanogaster mutants by X-chromosome
N. Matiytsiv*, ². Mohylyak, Ya. Chernyk
Ivan Franko National University of Lviv
4, Hrushevskyi St., Lviv 79005, Ukraine
Degenerative changes in the brain often are caused by the point mutations in single genes. Determination of these genes, their products and features of the morphological changes in mutants gives an opportunity for better understanding of nature and mechanisms of neurodegenerative processes. We have obtained seven lines of Drosophila melanogaster neurodegenerative mutants by X-chromosome. There was no eggroll mutant among those lines, and mutations 2-14, 61-7, 72-7 and 76-15 were mapped in 7D1 region of Õ chromosome, and they seems to be a new allelic forms of swiss cheese gene.
Keywords: drosophila, neurodegeneration, eggroll, swiss cheese