Mechanisms of enhancement of antineoplastic activity of Ru2+-containing drug by immobilization on polymer carrier

Yu. Senkiv1,2,3, A. Ryabtseva3, N. Boiko1, N. Mitina3, O. Zaichenko4, R. Stoika1

1Institute of Cell Biology, NAS of Ukraine
14/16, Drahomanov St., Lviv 79005, Ukraine
2Ivan Franko National University of Lviv
4, Hrushevskyi St., Lviv 79005, Ukraine
3National University “Lviv Polytechnic”
2, St. George Sq., Lviv 79013, Ukraine

The effectiveness of treatment of malignant tumors by the recently created (Ru2+)-containing anticancer drug is significantly reduced by its serum proteins binding in the human body. We have discovered a method of drug protecting from the binding with albumin and transferrin by encapsulating this drug in new polymer poly(VEP-GMA)-graft-PEG. Besides, this encapsulation of anticancer drug encourage more effective its accumulation and increase from 2 to 22 times its efficiency of actions (depending on the cell line) in malignant human cells.

Keywords: cancer cells, (Ru2+)-containing anticancer drug, encapsulation, polymer poly(VEP-GMA)-graft-PEG, efficiency of antineoplastic action

Full text (PDF)