Mechanisms of enhancement of antineoplastic activity of Ru2+-containing drug by immobilization on polymer carrier

Yu. Senkiv1,2,3, A. Ryabtseva3, N. Boiko1, N. Mitina3, O. Zaichenko4, R. Stoika1

1Institute of Cell Biology, NAS of Ukraine
14/16, Drahomanov St., Lviv 79005, Ukraine
2Ivan Franko National University of Lviv
4, Hrushevskyi St., Lviv 79005, Ukraine
3National University “Lviv Polytechnic”
2, St. George Sq., Lviv 79013, Ukraine
stoika@cellbiol.lviv.ua

The effectiveness of treatment of malignant tumors by the recently created (Ru2+)-containing anticancer drug is significantly reduced by its serum proteins binding in the human body. We have discovered a method of drug protecting from the binding with albumin and transferrin by encapsulating this drug in new polymer poly(VEP-GMA)-graft-PEG. Besides, this encapsulation of anticancer drug encourage more effective its accumulation and increase from 2 to 22 times its efficiency of actions (depending on the cell line) in malignant human cells.


Keywords: cancer cells, (Ru2+)-containing anticancer drug, encapsulation, polymer poly(VEP-GMA)-graft-PEG, efficiency of antineoplastic action


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