Effect of L-glutamic acid on the activity of glutathione metabolism enzymes and intencity of peroxidation processes in rats

N. Salyha,Yu. Salyha

Institute of Animal Biology NAAS of Ukraine
38, V. Stus St., Lviv 79034, Ukraine

The effect of additional (10% and 25% respectively) administration of L-glutamic acid (L-Glu) into the diet of rats on the activity of antioxidant enzymes and intensity of peroxidation processes in tissues of brain and heart was studied. We found that the ratís diet enrichment by L-Glu during 30 days resulted in a change of glutathione part of antioxidant system and intensity of lipid peroxidation processes. It is shown that additional L-Glu levels leads to increasing of glutathione peroxidase activity and the content of reduced glutathione and to reduction of lipid hydroperoxides and TBA-active products in heart tissues compared with the control group of animals. More intensive changes in these indices were observed in animals of the second experimental group which received additional 25% of L-Glu into the diet.

Keywords: L-glutamic acid, glutathione peroxidase, glutathione reductase, glutathione reduced, lipids hydroperoxides, TBA-active products

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