Investigation of glutathione system under inhibition of tumor growth
O. Bilenko, M. Rudenko, I. Leus, S. Babiy, O. Skorik, N. Shtemenko
Oles Gonchar Dnipropetrovsk National University
72, Gagarin Ave., Dnipropetrovsk 49010, Ukraine
The influence of new cluster rhenium compound with ferulic acid as the organic ligand and cis-platinum on the activity of glutathione peroxidase, glutathione transferase and the content of reduced glutathione in rat blood in experimental carcinoma Guerin have been studied. The obtained data demonstrate certain changes in glutathione dependent system of blood under inhibition of tumor growth by research compounds. The effect of the mixed nanoliposome rhenium-platinum system is more pronounced than a single administration of the test substances in cancer. It is shown (in group [Referul+cPt(4:1)]) the effective antitumor activity marked increasing glutathione levels and glutathione peroxidase activity and reducing glutathione-S-transferase activity. It is concluded that, in contrast to a single injection of cisplatin, the introduction of platinum-rhenium system promoted increasing antioxidant capacity of the body and stabilizing the studied parameters.
Keywords: glutathione, glutathione peroxidase, glutathione S-transferase, cisplatin, rhenium-platinum system