Sensitivity to the oxidative stress conditions lifespan and neurodegenerative changes in the brain structure of Drosophila melanogaster superoxiddismutase mutants

M. Vitushinska, N. Matiytsiv, Ya. Chernik

Ivan Franko National University of Lviv
4, Hrushevskyi St., Lviv 79005, Ukraine

Have been traced the change in intensity of lipid peroxidation, viability and degenerative changes in the brain structure of adult D. melanogaster Sod1 and Sod2 mutants under standard conditions and under conditions of oxidative stress (OS). All the results indicate an increased sensitivity of mutant flies to OS conditions, and phenotype manifestations depend on the genotype and age of individuals.

Keywords: Drosophila, oxidative stress, superoxidedismutase, life span, neurodegeneration

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