The influence of tissue specific inhibition of sws gene expression on Drosophila melanogaster compound eye formation

I. Mohylyak*, N. Matiytsiv, Ya. Chernyk

Ivan Franko National University of Lviv
4, Hrushevskyi St., Lviv 79005, Ukraine

We have determined the influence of tissue specific inhibition of swiss cheese gene on formation and functioning of Drosophila melanogaster compound eye. The presence of functional SWS protein is essential for glia of lamina, and inhibition of SWS translation in optic lobe leads to the strong degeneration phenotype appearance. Comparing to optic lobe, knock out of sws only in eye is less deleterious. Further narrowing areas of sws inhibition to cone cells of the eye and R7 and R8 photoreceptors, has no visible effect on adult eye and neuropile structure, suggesting that the SWS role in eye is not highly important. This suggestion is also proved by the regular structure of p25 and p45 eye imaginal discs, and intact “biocrystalline” structure of adult flies eyes, with functional inhibition of sws gene.

Keywords: Drosophila, neurodegeneration, sws, NTE, Gal4-UAS transgenic expression

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