Transformation of cholesterol in rats’ organs with experimental hypercholesterinemia and its correction
Institute of Animals Biology, NAS of Ukraine
38, V. Stus St., Lviv 79034, Ukraine
Hypercholesterinemia in rats created daily, for 90 days, feeding in the food chemically pure cholesterol in quantities of 300 mg/kg body weight. The experimental hypercholesterinemia corrected feeding pharmacopoeial fish oil in quantities of 1 ml/kg body weight. Fish oil is also fed during the above period. As a result of studies found, that fed fish oil accelerates cholesterol transformation into bile acids, testosterone, 25–OH–vitamin D3, cortisol and aldosterone in rats’ organs with experimental hypercholesterinemia. Thus, the concentrations of bile acids, testosterone, 25–OH–vitamin D3, cortisol and aldosterone in rats’ blood were increased.
Keywords: experimental hypercholesterinemia, bile acids, testosterone, vitamine D3, cortisol, aldosterone, rats