Effects of N-stearoylethanolamine and chronic alcoholization on behavior of rats in “open-field”

O. Bondarenko1, N. Gulaya2, M. Makarchuk1, T. Goridko2, V. Baban1, O. Kovalenko1

1Taras Shevchenko National University of Kyiv, Educational and Scientific Centre «Institute of Biology»
2, Academician Glushkov Ave., Kyiv 03022, Ukraine
2Palladin Institute of Biochemistry of the NAS of Ukraine (NASU)
9, Leontovych St., Kyiv 01601, Ukraine

The behavioral reactions of rats after administration of alcohol and N-stearoylethanolamine (NSE) were investigated using “open field” test. It was observed that alcohol, NSE or both was able to change the behavior of rats in the open field. It was found that administration of NSE in the dose of 5 mg/kg during 7 days leaded to reduction of vertical and locomotor activity and had no effect on the parameters of the emotional activity (duration of grooming). Administration of the NSE during the last 7 day of 30-days chronic alcoholization resulted in slight reduction of the rat’s motivation of the alcohol consumption in the case of free choice. At the same time, significant differences of behavior in «Alcohol» and «Alcohol and NSE» groups in open field weren’t found.

Keywords: N-stearoylethanolamine, “open field” test, behavior, alcohol, dependence

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