Treatment and prophylactic preparates of bacteriophages
E. Vorobey, O. Voronkova, E. Sirokvasha, A. Vinnikov
Oles Gonchar Dnipropetrovsk National University
72, Gagarin Ave., Dnipropetovsk 49010, Ukraine
The review is devoted to the issues of the current state of production and use of bacteriophages as antimicrobial drugs for prevention and treatment bacterial infection. The need to find the solution of the question arises through the dissemination of the sustainability of clinical isolates of bacteria to antibiotics, which defines a reduction in the effectiveness of antibioti˝therapy in general. Disclosed historical aspects of the production and use of bacteriophages, analyzed information about the mechanism of interaction, efficiency of bacteriophage preparations and existing problems of phages in treatment of the defeats caused by biofilm-forming strains of bacteria. The data reveal the possibility of the use of medicinal drugs of bacteriophages as one of the promising directions for practical public health.
Keywords: resistance to antibiotics, bacteriophages, production, biofilm formation, phage therapy