Effect of N-stearoylethanolamine in different doses on behavior of rats after chronic alcoholization in “open-field”

O. Bondarenko1, N. Gula2, M. Makarchuk1, T. Goridko2

1Taras Shevchenko National University of Kyiv, Educational and Scientific Centre «Institute of Biology»
2, Academician Glushkov Ave., Kyiv 03022, Ukraine
2Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine (NASU)
9, Leontovycha St., Kyiv 01601, Ukraine
bondarenko_ _oleksandr@ukr.net

The effect of N-stearoylethanolamine (NSE) administration (isolated and combined with alcoholization) at a dose of 0.1 and 5 mg/kg on the behavior reactions of rats in the “open field” test was investigated. For the first time ever it was revealed that the introduction of NSE at a dose of 0.1 mg/kg and 5 mg/kg produced a different effect on the rats’ behavior after alcoholization in the “open field” compared with intact animals. In addition to the above the effects of the introduction of low and high doses of NSE to the intact rats and rats after alcoholization are diametrically opposed, which may indicate the involvement of different neurophysiological mechanisms in implementation of the effects of low and high doses of NSE on the behavior of the intact animals and animals after alcoholization.

Keywords: N-stearoylethanolamine, open field, behavior, alcohol

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