Prognostic value of aneuploidy and polyploidy in colorectal cancerogenesis
M. Lozynska1, R. Lozynskyy2
1SI ĞInstitute of Hereditary Pathology of NAMS of Ukraineğ
31-à, M. Lysenko St., Lviv 79000, Ukraine
2SI ĞInstitute of Blood Pathology and Transfusion Medicine of NAMS of Ukraineğ
45, General Chuprynka St., Lviv 79044, Ukraine
It was carried out the cytogenetic examination of the colorectal polyps and adenocarcinoma samples from 58 patients with neoplasia, who lived in west regions of Ukraine. The most typical chromosomal abnormality in the samples of hyperplastic polyps and adenomas was aneuploidy of chromosomes 13, 7, and 20. The transformation of tubular adenomas in tubulovillous and in villous adenomas was accompanied with increasing number of chromosome abnormalities and widening of its spectrum. The majority of the adenocarcinoma samples showed polysomic karyotype, ranging from near-triploid and near-tetraploid to even higher number of chromosomal sets. The appearance of the additional copies of chromosomes 20, 7, 2, 5 and allelic losses of chromosomes 18, 17, 6, 14, 1, and the chromosome deletions of various sizes may be significant in colorectal tumorogenesis.
Keywords: hyperplastic polyps, adenomas, aneuploidy, polyploidy, colorectal cancer