Change of level of LCA- and LABA-binding of α1-acid glycoprotein and fibronectin under the influence of cytostatics chemotherapy in patients with chronic lymphocytic leukemia
State Institution “Dnipropetrovsk Medical Academy”
9, Dzerjynskyi St., Dnipropetrovsk 49001, Ukraine
Level of LCA- and LABA-binding of fibronectin (FN) and α1-acid glycoprotein (AGP) in the plasma of patients with chronic lymphocytic leukemia (CLL) before treatment and at its different stages were studied by lectin-enzyme analysis. The numbers of fibronectin LCA-binding glycoforms in the plasma of patients with CLL and the first day after treatment were lower than the control, and were significantly increased after two months of cytostatic therapy. The degree of AGP LCA-binding was increased in CLL patients and did not change during treatment, indicating a lack of effect of cytostatic therapy on the AGP α1,6-fucose glycotope. Values of plasma fibronectin and AGP LABA-binding in patients with CLL were related and the correlation was significantly decreased after treatment, and can be used to assess the results of therapy in such patients.
Keywords: fibronectin, α1-acid glycoprotein, fucosylation, chronic lymphocytic leukemia, cytostatic therapy