Quantitative and qualitative composition of microflora in a large intestine of rats when using the oral preservative nipagin

N. Skochylyas, Ya. Kolisnyk

Ivan Franko National University of Lviv
4, Hrushevskyi St., Lviv 79005, Ukraine

It was established that antimicrobial preservative nipagin, which was intragastrically administered to rats at a dose of 10 mg/kg, caused the decreasing of number of autochthonous obligate microorganisms of genera Escherichia, Streptococcus, Candida (on 4th day of studies). Bifidobacterium Peptostreptococcus, Enterococcus (7th day), Eubacterium (11th day) in abdominal microflora of the large intestine. Under these conditions there was an increasing of number of bacteria of genera Staphylococcus, Proteus and Clostridium on 4th, 7th and 11th days, respectively. The constant representatives of the abdominal microflora of the experimental animals, compared with those in rats of the control group, are Prevotella, Clostridium, Proteus, lactosonegative Escherichia sp. and bacteria P. aeruginosa.

Keywords: nipagin, microflora, cavity of the colon

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