The influence of calcitonin on spectrum of bilirubin conjugates in rats bile

². Vasheka1, S. Veselsky1, Z. Gorenko1, L. Karbovska2, O. Grinchenko1

1Petro Bohach Scientific Research Institute, Institute of Biology Taras Shevchenko National University of Kyiv
2, Hlushkov Ave., Kyiv 03022, Ukraine
2Taras Shevchenko National University of Kyiv Institute of Biology
2, Hlushkov Ave., Kyiv 03022, Ukraine
vasheka88@ya.ru

The influence of calcitonin on the choleresis level and spectrum of bilirubin conjugates was investigared in acute experiments on the rats with common billiary duct cannulated. It was shown that administration of calcitonin at doses 200 and 800 ng/kg body weight increases the secreted bile volume. The intramuscular introduction of calcitonin at dose 200 ng/kg body weight statistically significant decreases absolute content of unconjugated bilirubin and increases content of sulphate of bilirubin. The administrstion of calcitonin at dose 800 ng/kg body weight statistically significant increases absolute content of sulphate of bilirubin, monoglucuronid and monoglucuronidmonoglucoside of bilirubin. Significant changes in the absolute content of diglucuronid of bilirubin by the action of both doses of calcitonin is not observed.


Keywords: calcitonin, sulphate of bilirubin, diglucuronid of bilirubin, monoglucuronid of bilirubin, monoglucuronidmonoglucoside of bilirubin


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