The state of colon mucosa of rats treated with different doses of cytostatic compound pyrrol derivative
M. Yena, H. Kuznietsova, V. Rybalchenko
Taras Shevchenko National University of Kyiv
64/13, Volodymyrska St., Kyiv 01601, Ukraine
The purpose of the work was to evaluate the effect of the high doses of pyrrole tyrosine kinase inhibitor 5-amino-4-(1,3-benzothiazol-2-yl)-1-(3-methoxyphenyl)-1,2-dihydro-3Í-pyrol-3-one (D1), which according to the previous data exerts antitumor activity in vivo and has low toxicity in the effective dose. The histological specimens of the colon mucosa stained with hematoxylin and eosin were studied. It was found out that dihydropyrrole derivate when acting at the conditionally effective (inhibits the tumor growth at the level of the traditional cytostatic drug, 5-fluorouracil), 5-fold and 10-fold of the conditionally effective doses (2.3 mg/kg, 11.5 mg/kg and 23 mg/kg, respectively) within 2 weeks had no negative effect on the rat colon mucosa. Absence of the significant pathological changes in colon under D1 effect shows the relative safety of this compound for the gastro-intestinal tract and its benefits as the potential antitumor compound which may be helpful to develop the diagnostic criteria in the clinical practice.
Keywords: pyrrol derivative, proximal colon mucosa