The effect of chromium citrate on pro/antioxidant status of ratsí pancreas under the condition of streptozotocin-induced diabetes mellitus
R. Iskra, O. Slivinska
Institute of Animal Biology, NAAS of Ukraine
38, V. Stus St., Lviv 79034, Ukraine
The influence of Chromium citrate (C6H5CrO7) in a quantity of 10 and 25 mcg —r3+/kg body weigh on the content of lipid peroxidation products and the activity of antioxidant defense system enzymes in pancreas of rats under the condition of streptozotocin-induced diabetes mellitus was researched. It was established that MDA content, the activity of superoxide dismutase were increased, while the activity of catalase, glutathione reductase and the content of reduced glutathione were decreased compared to the control group. Addition of chromium citrate in a quantity of 10 mcg —r3+/kg body weight to the diet of rats led to the increased activity of glutathione peroxidase, glutathione reductase and the content of reduced glutathione in pancreas, while the addition of this compound in a quantity of 25 mcg —r3+/kg body led to the decreased content of the MDA, activity of superoxide dismutase, but increased activity of catalase, glutathione peroxidase, glutathione reductase and the content of reduced glutathione compared to their levels in animals from group II with an experimental diabetes.
Keywords: rats, diabetes mellitus, pancreas, antioxidant system