DNMT3B -149C>T and DNMT3B -579G>T allelic polymorphisms among patients with oncological disease
SI “Institute of Hereditary Pathology of the UNAcademy of Medical Sciences»
31A, Lysenka St., Lviv 79000, Ukraine
DNMT3B -149C>T and DNMT3B -579G>T single-nucleotide polymorphism is modulating the gene expression, which lead to DNA methylation changing and may be a cancer susceptibility factor. Molecular-genetic analysis of -579G> T DNMT3B polymorphic loci shows the following value in frequency of 579GG, 579GT and 579TT genotypes: 0.35, 0.47 and 0.18 in control group, 0.33, and 0.54 0.13 in group of patients with breast cancer, 0,27,0,5 and 0.23 in group of persons with leukemia. The distribution of 149 CC, 149CT and 149TT genotype frequencies of DNMT3B 149C> T polymorphism showed the following values: 0.32, 0.45 and 0.23 in the control group, 0.29, 0.51 and 0.20 in group of persons with cancer breast, 0.22, 0.48 and 0.30 in group of patients with leukemia. The distribution of genotypes and alleles of DNMT3B -149C>T and -579G>T polymorphisms in groups of patients with breast cancer and leukemia did not show statistically significant differences compared to control group.
Keywords: methylation, DNA-methyltransferase-3B, polymorphism, breast cancer, leukemia