Influence of yañon (Smallanthus sonchifolius Poepp. & Endl.) on rats’ blood cells the condition of experimental diabetes mellitus

A. Horbulinska1, M. Khokhla1, G. Hachkova1, L. Mishchenko2, R. Vildanova3, O. Shulga3, N. Sybirna1

1 Ivan Franko National University of Lviv
4, Hryshevskyi St., Lviv 79005, Ukraine
2 Taras Shevchenko National University of Kyiv
64/13, Volodymyrska St., Kyiv 01601, Ukraine
3 Department of Physical Chemistry of Combustible Minerals L.M. Lytvynenko Institute of Physico-Organic Chemistry and Coal Chemistry NAS of Ukraine
3a, Naukova St., Lviv 79060, Ukraine

Yacon (Smallanthus sonchifolius Poepp. & Endl.) – perennial plant that belong to asteraceae family. It traditionally grown in the northern and central Andes from Colombia to northern Argentina. Yacon recently been introduced in Ukraine and were studied fructooligosaccharides content (FOS) and phenolic compounds in it. It was shown that leaves of yacon contain significant amounts of phenolic compounds (protocatechuic, chlorogenic, caffeic, ferulic and rosmarinic acids), and they are rich in sesquiterpene lactones – enhydrin and smallanthaditerpenic acids A, B, C, D. Root tubers of yacon contain phenolic compounds major part of which is chlorogenic and caffeic acids. They also are rich in essential amino acid tryptophan. The main value of root tubers of yacon as a source of biologically active substances is that they are contain FOS. In particular it was shown that inulin content reaches 60%. The article contain data about the influence of aqueous extracts of leaves and roots and suspensions of yacon tubers root powder on rats erythron system state under experimental diabetes mellitus (EDM). As a result of our studies was shown prominent hypoglycemic effect of leaves and root tubers of yacon as in the form of extracts, and in the form of suspensions. Pathogenesis of diabetes is accompanied by significant changes in physical, biochemical and morphological properties of red blood cells. The application of studied extracts and suspensions under conditions of EDM has a positive corrective effect on the erythron system, causing reduction in the number and daily production of reticulocytes and increase in erythrocyte membranes resistance to acidic hemolytic action. The combination of hypoglycemic effect and normalizing effect on peripheral blood of extracts and suspensions of yacon is a reason for the recommendations of this plant as the basis for creating medications for combined therapy of diabetes complications.

Keywords: yacon (Smallanthus sonchifolius Poepp. & Endl.) diabetes mellitus, erythrocytes, phytotherapy

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